Numerous publications published in the open literature report investigations on local delivery systems containing antimicrobial drugs, which – alone or in combination with other dental procedures – may result in a more efficient treatment. 4 Systemically administered antibiotics may not be present in sufficient concentration in the periodontal pocket therefore, they are often ineffective, while the common side effects of antimicrobial therapy could occur. The management of periodontal disease includes the mechanical removal of biofilm with or without the adjunctive use of systemic antibiotics. The elimination of biofilm and/or hard deposits (mineralized biofilm) is the cornerstone of periodontal treatment. 1, 2 This disease is the most prevalent reason for tooth loss among adults.
Conditions in the periodontal pocket are suitable for bacterial proliferation and result in dysbiosis owing to a breakdown in host-microbe homeostasis. The inflammation of periodontal tissue causes bone destruction by osteoclastic resorption together with tissue destruction, and the detachment of junctional epithelium result in periodontal pocket formation. Periodontitis is an inflammatory disease resulting from the overgrowth of subgingival polymicrobial community in susceptible hosts affecting the tissues surrounding the teeth. Keywords: drug release devices, fiber mats, disks, morphology, dissolution, capillary forces, diffusion, antimicrobial, inhibition
The longer inhibition period could be explained by the slower diffusion of metronidazole located inside the fibers of the device.Ĭonclusion: The results suggest that the devices may be effective in the treatment of periodontitis. Although the release study indicated fast drug dissolution, the concentration achieved a plateau value in 24 hrs for the disks the inhibition effect lasted much longer, 13 days for bacteria sensitive to metronidazole. Disks released the drug much faster than fiber mats. Liquid penetration and dissolution were different in the two devices, they were faster in disks and slower in fiber mats, due to the morphology of the device and the action of capillary forces. Results: The XRD study showed that the polymer was partially crystalline in both devices, but a part of metronidazole precipitated and was in the form of crystals among and within the fibers. Methods: The structure was studied by X-ray diffraction and scanning electron microscopy, drug release by dissolution measurements, while the antimicrobial efficiency was tested on five bacterial strains. Metronidazole was used as an active agent its concentration was 12.2 and 25.7 wt% in the devices.
Purpose: Electrospun PLA fiber devices were investigated in the form of fiber mats and disks. Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, Szeged 6720, Hungary Mária Budai-Szűcs, 1 Attila Léber, 1 Lu Cui, 2, 3 Muriel Józó, 2, 3 Péter Vályi, 4 Katalin Burián, 5 Balázs Kirschweng, 2, 3 Erzsébet Csányi, 1 Béla Pukánszky 2, 3ġInstitute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, Hungary 2Laboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest H-1521, Hungary 3Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1519, Hungary 4Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged, Hungary 5Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
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